Ion-channel families

60 IUPHAR/BPS families · 354 genes. Expand a family to see its channels; click a channel for its atlas page.

26 Voltage-gated Ca2+ VG_Ca2

CACNA1A CACNA1B CACNA1C CACNA1D CACNA1E CACNA1F CACNA1G CACNA1H CACNA1I CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8

21 Gap junction (Connexin) Gap

GJA1 GJA10 GJA3 GJA4 GJA5 GJA8 GJA9 GJC1 GJC2 GJC3 GJD2 GJD3 GJD4 GJE1 GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7

19 Ligand-gated (GABA-A) Ligand

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GABRE GABRG1 GABRG2 GABRG3 GABRP GABRQ GABRR1 GABRR2 GABRR3

16 Inward rectifier K+ VG_K

KCNJ1 KCNJ10 KCNJ11 KCNJ12 KCNJ13 KCNJ14 KCNJ15 KCNJ16 KCNJ18 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ8 KCNJ9

16 Ligand-gated (nAChR) Ligand

CHRNA1 CHRNA10 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNA9 CHRNB1 CHRNB2 CHRNB3 CHRNB4 CHRND CHRNE CHRNG

15 Two-pore K+ VG_K

KCNK1 KCNK10 KCNK12 KCNK13 KCNK15 KCNK16 KCNK17 KCNK18 KCNK2 KCNK3 KCNK4 KCNK5 KCNK6 KCNK7 KCNK9

14 Voltage-gated Na+ VG_Na

SCN10A SCN11A SCN1A SCN1B SCN2A SCN2B SCN3A SCN3B SCN4A SCN4B SCN5A SCN7A SCN8A SCN9A

12 Aquaporin VG_K

AQP1 AQP2 AQP3 AQP4 AQP5 AQP6 AQP7 AQP8 AQP9 AQP10 AQP11 MIP

10 Chloride (Anoctamin/TMEM16) Cl

ANO1 ANO10 ANO2 ANO3 ANO4 ANO5 ANO6 ANO7 ANO8 ANO9

9 Chloride (CLC) Cl

CLCN1 CLCN2 CLCN3 CLCN4 CLCN5 CLCN6 CLCN7 CLCNKA CLCNKB

8 TRP (Melastatin) TRP

TRPM1 TRPM2 TRPM3 TRPM4 TRPM5 TRPM6 TRPM7 TRPM8

8 Voltage-gated K+ (ether-a-go-go) VG_K

KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8

8 Voltage-gated K+ (Shaker) VG_K

KCNA1 KCNA10 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7

7 Ligand-gated (NMDA) Ligand

GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B

7 Ligand-gated (P2X) Ligand

P2RX1 P2RX2 P2RX3 P2RX4 P2RX5 P2RX6 P2RX7

7 Sperm cation (CatSper) VG_Ca2

CATSPER1 CATSPER2 CATSPER3 CATSPER4 CATSPERB CATSPERG CATSPERZ

7 TRP (Canonical) TRP

TRPC1 TRPC2 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7

6 Chloride (CLIC) Cl

CLIC1 CLIC2 CLIC3 CLIC4 CLIC5 CLIC6

6 Cyclic nucleotide-gated (CNG) HCN

CNGA1 CNGA2 CNGA3 CNGA4 CNGB1 CNGB3

6 Mitochondrial Ca2+ uniporter (MCU) VG_K

MCU MCUB MICU1 MICU2 MICU3 SMDT1

6 TRP (Vanilloid) TRP

TRPV1 TRPV2 TRPV3 TRPV4 TRPV5 TRPV6

5 Calcium-activated K+ (BK) VG_K

KCNMA1 KCNMB1 KCNMB2 KCNMB3 KCNMB4

5 Ligand-gated (5-HT3) Ligand

HTR3A HTR3B HTR3C HTR3D HTR3E

5 Ligand-gated (ASIC) Ligand

ASIC1 ASIC2 ASIC3 ASIC4 ASIC5

5 Ligand-gated (Glycine) Ligand

GLRA1 GLRA2 GLRA3 GLRA4 GLRB

5 Ligand-gated (Kainate) Ligand

GRIK1 GRIK2 GRIK3 GRIK4 GRIK5

5 Voltage-gated K+ (beta) VG_K

KCNE1 KCNE2 KCNE3 KCNE4 KCNE5

5 Voltage-gated K+ (Kv7) VG_K

KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5

5 Volume-regulated anion (VRAC) Cl

LRRC8A LRRC8B LRRC8C LRRC8D LRRC8E

4 Calcium-activated K+ (SK/IK) VG_K

KCNN1 KCNN2 KCNN3 KCNN4

4 Chloride (Bestrophin) Cl

BEST1 BEST2 BEST3 BEST4

4 Epithelial Na+ (ENaC) VG_Na

SCNN1A SCNN1B SCNN1D SCNN1G

4 HCN (pacemaker) HCN

HCN1 HCN2 HCN3 HCN4

4 Ligand-gated (AMPA) Ligand

GRIA1 GRIA2 GRIA3 GRIA4

4 TRP (Polycystin) TRP

PKD1 PKD2 PKD2L1 PKD2L2

4 Voltage-gated K+ (Kv6) VG_K

KCNG1 KCNG2 KCNG3 KCNG4

4 Voltage-gated K+ (Shaw) VG_K

KCNC1 KCNC2 KCNC3 KCNC4

3 IP3 receptor Ca_store

ITPR1 ITPR2 ITPR3

3 Large-pore (CALHM) Gap

CALHM1 CALHM2 CALHM3

3 Large-pore (Pannexin) Gap

PANX1 PANX2 PANX3

3 Mechanosensitive (OSCA/TMEM63) TRP

TMEM63A TMEM63B TMEM63C

3 Ryanodine receptor Ca_store

RYR1 RYR2 RYR3

3 Store-operated (Orai) Ca_store

ORAI1 ORAI2 ORAI3

3 TRP (Mucolipin) TRP

MCOLN1 MCOLN2 MCOLN3

3 Voltage-gated K+ (Kv9) VG_K

KCNS1 KCNS2 KCNS3

3 Voltage-gated K+ (Shal) VG_K

KCND1 KCND2 KCND3

2 Endolysosomal (Two-pore, NAADP) Ca_store

TPCN1 TPCN2

2 Ligand-gated (Glutamate delta) Ligand

GRID1 GRID2

2 Mechanosensitive (Piezo) TRP

PIEZO1 PIEZO2

2 Sodium-activated K+ (KNa) VG_K

KCNT1 KCNT2

2 Store-operated (STIM) Ca_store

STIM1 STIM2

2 Voltage-gated K+ (Kv8) VG_K

KCNV1 KCNV2

2 Voltage-gated K+ (Shab) VG_K

KCNB1 KCNB2

1 Chloride (CFTR) Cl

CFTR

1 Ligand-gated (Zinc-activated) Ligand

ZACN

1 Sodium leak (NALCN) VG_K

NALCN

1 Sperm Ca2+/Na+-activated K+ (Slo3) VG_K

KCNU1

1 TRP (ANKTM1) TRP

TRPA1

1 Voltage-gated K+ (Kv5) VG_K

KCNF1

1 Voltage-gated proton (Hv1) VG_K

HVCN1