A single-cell map of the human ion channelome.
CATION charts 354 curated ion-channel genes across 58 tissues and 738 cell types, integrated from 10.0M cells. Porecast then predicts each cell type's electrical behaviour from its channel fingerprint.
Each tissue is coloured by its dominant electrical regime. Click a region.
Every cell type has a regime.
Porecast turns each cell's ion-channel fingerprint into a Hodgkin–Huxley conductance vector and reads off a bifurcation-defined electrical regime.
- 536 Quiescent flat baseline — resting potential
- 154 Excitable single action-potential spike
- 48 Rhythmic repeating pacemaker spike-train
of 738 cell types · external donor-held-out prediction R² 0.416 vs 0.342 expression-only ceiling.
From channel expression to an electrical regime.
Porecast — the method companion to CATION — converts a cell type's ion-channel fingerprint into a conductance vector and reads off the bifurcation-defined regime, quiescent, excitable, or rhythmic, with calibrated abstention.
Explore the atlas
Set in Spectral & IBM Plex · built 2026-07-14 · CATION vv1.0-354 · about & credits