cation · a human ion-channel atlas release v1.0-354 · 10.0m cells
CATION Cell ATlas of ION channels

Tissues · 100,000 cells

cortex

Cells
100,000
Top channel
GRIA2
Cell types present
46
Share of atlas cells
1.0%
plate vi-a — top channels

Top ion channels in cortex

Ranked mean expression across cell types; bars coloured by each channel's class.

  1. 01 GRIA2 Ligand-gated 1.242
  2. 02 GRIK2 Ligand-gated 1.184
  3. 03 KCNMA1 Voltage-gated K⁺ 1.174
  4. 04 KCNQ3 Voltage-gated K⁺ 1.086
  5. 05 GRID2 Ligand-gated 1.018
  6. 06 KCNQ5 Voltage-gated K⁺ 1.001
  7. 07 RYR2 Ca²⁺ store 0.995
  8. 08 GRIA1 Ligand-gated 0.985
  9. 09 GRIN2B Ligand-gated 0.949
  10. 10 CACNA1C Voltage-gated Ca²⁺ 0.943
  11. 11 CACNA2D3 Voltage-gated Ca²⁺ 0.925
  12. 12 CACNA2D1 Voltage-gated Ca²⁺ 0.923
  13. 13 GRIN2A Ligand-gated 0.879
  14. 14 CACNB2 Voltage-gated Ca²⁺ 0.836
  15. 15 GRIA4 Ligand-gated 0.831
plate vi-b — cell types in this tissue

46 cell types

Ranked by total ion-channel expression. Dominant class = the channel class carrying the largest share of this cell type's expression.

Cell typeDominant classTotal channel expression
corticothalamic-projecting glutamatergic cortical neuron Ca²⁺ store 3.263
L5 extratelencephalic projecting glutamatergic cortical neuron Ca²⁺ store 3.198
L6b glutamatergic neuron of the primary motor cortex Ca²⁺ store 3.099
L6 corticothalamic-projecting glutamatergic cortical neuron Ca²⁺ store 3.073
L2/3-6 intratelencephalic projecting glutamatergic neuron Voltage-gated Ca²⁺ 3.066
sst GABAergic cortical interneuron Voltage-gated Ca²⁺ 2.970
L2/3 intratelencephalic projecting glutamatergic neuron Voltage-gated Ca²⁺ 2.932
near-projecting glutamatergic cortical neuron Voltage-gated Ca²⁺ 2.867
L6 intratelencephalic projecting glutamatergic neuron of the pri Voltage-gated Ca²⁺ 2.864
L6b glutamatergic cortical neuron Ca²⁺ store 2.837
sncg GABAergic cortical interneuron Voltage-gated Ca²⁺ 2.834
L5/6 near-projecting glutamatergic neuron Voltage-gated Ca²⁺ 2.817
L6 intratelencephalic projecting glutamatergic neuron Voltage-gated Ca²⁺ 2.778
chandelier pvalb GABAergic cortical interneuron Ligand-gated 2.769
lamp5 GABAergic cortical interneuron Voltage-gated Ca²⁺ 2.737
L5/6 near-projecting glutamatergic neuron of the primary motor c Ligand-gated 2.732
VIP GABAergic cortical interneuron Voltage-gated Ca²⁺ 2.721
GABAergic interneuron Voltage-gated Ca²⁺ 2.680
medial ganglionic eminence derived interneuron Voltage-gated Ca²⁺ 2.337
cortical interneuron Ligand-gated 2.116
intratelencephalic-projecting glutamatergic cortical neuron Voltage-gated Ca²⁺ 1.962
inhibitory interneuron Voltage-gated Ca²⁺ 1.874
GABAergic neuron Voltage-gated Ca²⁺ 1.766
astrocyte of the cerebral cortex Ca²⁺ store 1.727
caudal ganglionic eminence derived cortical interneuron Ligand-gated 1.705
forebrain neuroblast Ligand-gated 1.474
cerebral cortex endothelial cell Ca²⁺ store 1.271
brain vascular cell Ca²⁺ store 1.138
perivascular macrophage Ca²⁺ store 0.983
vascular leptomeningeal cell Ca²⁺ store 0.972
microglial cell Ca²⁺ store 0.947
central nervous system macrophage Ca²⁺ store 0.937
oligodendrocyte Chloride 0.887
mural cell Ca²⁺ store 0.845
neural cell Ca²⁺ store 0.776
pericyte Ca²⁺ store 0.657
perivascular cell Ca²⁺ store 0.606
cerebral cortex neuron Voltage-gated Na⁺ 0.576
mature astrocyte Ca²⁺ store 0.573
neuroblast (sensu Nematoda and Protostomia) Voltage-gated Ca²⁺ 0.532
medial ganglionic eminence derived GABAergic cortical interneuro Ligand-gated 0.509
vein endothelial cell Ca²⁺ store 0.446
natural killer cell Ca²⁺ store 0.353
T cell Ca²⁺ store 0.343
forebrain radial glial cell Voltage-gated K⁺ 0.327
cerebral cortex GABAergic interneuron Voltage-gated K⁺ 0.190