cation · a human ion-channel atlas release v1.0-354 · 10.0m cells
CATION Cell ATlas of ION channels

Tissues · 282,865 cells

colon

Cells
282,865
Top channel
CLIC1
Cell types present
28
Share of atlas cells
2.8%
plate vi-a — top channels

Top ion channels in colon

Ranked mean expression across cell types; bars coloured by each channel's class.

  1. 01 CLIC1 Chloride 1.211
  2. 02 SMDT1 Voltage-gated K⁺ 0.699
  3. 03 CLIC4 Chloride 0.228
  4. 04 ITPR2 Ca²⁺ store 0.219
  5. 05 MICU2 Voltage-gated K⁺ 0.203
  6. 06 CLCN3 Chloride 0.180
  7. 07 MICU1 Voltage-gated K⁺ 0.166
  8. 08 STIM2 Ca²⁺ store 0.160
  9. 09 ORAI2 Ca²⁺ store 0.159
  10. 10 P2RX4 Ligand-gated 0.148
  11. 11 TRPM7 TRP 0.136
  12. 12 TMEM63A TRP 0.129
  13. 13 AQP3 Voltage-gated K⁺ 0.126
  14. 14 ITPR1 Ca²⁺ store 0.123
  15. 15 MCU Voltage-gated K⁺ 0.122
plate vi-b — cell types in this tissue

28 cell types

Ranked by total ion-channel expression. Dominant class = the channel class carrying the largest share of this cell type's expression.

Cell typeDominant classTotal channel expression
intestinal enteroendocrine cell Voltage-gated Ca²⁺ 0.890
gut absorptive cell Ca²⁺ store 0.613
colon endothelial cell Ca²⁺ store 0.581
neoplastic cell Ca²⁺ store 0.566
tuft cell of colon Ca²⁺ store 0.460
type EC enteroendocrine cell Chloride 0.449
enterocyte of epithelium of large intestine Chloride 0.435
BEST4+ colonocyte Chloride 0.423
tuft cell of small intestine Ca²⁺ store 0.423
motor neuron Voltage-gated Na⁺ 0.411
secretory cell Chloride 0.398
stem cell Chloride 0.375
colon macrophage Ca²⁺ store 0.368
type L enteroendocrine cell Voltage-gated Ca²⁺ 0.366
intestinal crypt stem cell of colon Chloride 0.310
colon epithelial cell Chloride 0.308
early colonocyte Chloride 0.279
plasmablast Ca²⁺ store 0.277
effector memory CD4-positive, alpha-beta T cell Ca²⁺ store 0.260
TREM2-positive macrophage Ca²⁺ store 0.258
migratory enteric neural crest cell Chloride 0.241
transit amplifying cell of colon Chloride 0.213
reticular cell Ca²⁺ store 0.209
fibroblastic reticular cell Ca²⁺ store 0.209
T-helper 1 cell Ca²⁺ store 0.172
IgM plasma cell Ca²⁺ store 0.161
CD8-alpha-beta-positive, alpha-beta intraepithelial T cell Chloride 0.143
paneth cell Chloride 0.094