A single-cell atlas of the ion channelome
Every ion channel.
Every cell type.
One body.
CATION charts 354 curated ion-channel genes across 58 tissues and 738 cell types, integrated from 10.0M cells. Porecast then predicts each cell type's electrical behaviour from its channel fingerprint.
plate i — the human channelome, by regime
Quiescent Excitable Rhythmic
01 · genes 354 60 IUPHAR/BPS families
02 · cell types 738 54 tissues · 58 in release
03 · tissues 58 from CELLxGENE Census LTS 2025-11-08
04 · cells 10.0M 9,991,136 single cells
05 · regimes 536 / 154 / 48 quiescent · excitable · rhythmic
06 · validation R² 0.416 external donor-held-out, vs 0.342 expression ceiling
Every cell type has a regime.
Porecast turns each cell's ion-channel fingerprint into a Hodgkin–Huxley conductance vector and reads off a bifurcation-defined electrical regime.
- 536 Quiescent flat baseline — resting potential
- 154 Excitable single action-potential spike
- 48 Rhythmic repeating pacemaker spike-train
of 738 cell types · external donor-held-out prediction R² 0.416 vs 0.342 expression-only ceiling.
From channel expression to an electrical regime.
Porecast — the method companion to CATION — converts a cell type's ion-channel fingerprint into a conductance vector and reads off the bifurcation-defined regime, quiescent, excitable, or rhythmic, with calibrated abstention.