cation · a human ion-channel atlas release v1.0-354 · 10.0m cells
CATION Cell ATlas of ION channels

Porecast · electrical regime

The regime explorer.

Every one of 738 cell types carries a bifurcation-defined electrical regime, predicted by Porecast from its ion-channel fingerprint. Explore the conductance space where quiescent, excitable, and rhythmic cells separate — then inspect any cell's Hodgkin–Huxley conductance vector.

536 Quiescent flat baseline — resting potential
154 Excitable single action-potential spike
48 Rhythmic repeating pacemaker spike-train

The waveform glyph encodes the regime: a flat baseline = quiescent (resting potential), a single action-potential spike = excitable (threshold), a repeating spike-train = rhythmic (pacemaker). of 738 cell types · external donor-held-out prediction R² 0.416 vs 0.342 expression-only ceiling.

Method

Porecast converts each cell type's ion-channel expression into a Hodgkin–Huxley conductance vector (gNa, gK, gCa, gL) and solves for the fixed point / bifurcation structure, reading off the regime: quiescent-stable, excitable-bistable, or oscillatory-pacemaker. The dist-to-bifurcation measures how far a cell sits from the regime boundary — small values mark cells on the verge of a qualitative change in behaviour. Run the prediction yourself: pypi.org/project/porecast.